In which organ(s) is prilocaine biotransformed?

Prilocaine is biotransformed primarily in the liver and lungs. This is significant because understanding the metabolism of local anesthetics like prilocaine can influence clinical decisions, particularly regarding dosage and the management of potential side effects.

In the liver, prilocaine undergoes biotransformation through enzymes that facilitate its conversion into metabolites, including ortho-toluidine, which has implications for methemoglobinemia in certain patients. Additionally, the lungs play a crucial role in the uptake and clearance of prilocaine, further emphasizing their involvement in its metabolism.

The other choices do not represent the primary organs involved in the metabolism of prilocaine. The kidneys are involved in the excretion of metabolites but are not the primary site of biotransformation. The pancreas is not significantly involved in the metabolism of prilocaine, and while muscle tissues can have some impact on drug distribution, they are not key sites for biotransformation. Understanding the primary metabolic pathways is essential for safe and effective use of prilocaine in clinical practice.