Which of the following local anesthetics is known to have the least vasodilating effect?

Mepivacaine is recognized for having the least vasodilating effect among local anesthetics. This characteristic is significant because vasodilation can lead to increased blood flow at the injection site, which may affect the duration and effectiveness of the anesthesia. Mepivacaine’s lower vasodilatory properties contribute to its ability to maintain a longer action time without the need for vasoconstrictors, which are often used with other anesthetics to prolong their effects.

Lidocaine, bupivacaine, and articaine are known to have more pronounced vasodilating effects, which can influence their pharmacokinetics and duration of action. Thus, mepivacaine stands out for its unique profile, making it a favorable choice in situations where minimizing vasodilation is essential for optimal local anesthetic management.